In November 2006, Pausini released the album Io canto / Yo canto, consisting of covers of Italian pop rock songs. On the album liner notes, Pausini wrote: “here is the music I listen to when I’m at my saddest, or when I feel a moment is special, the songs I used to sing as a young girl when I first started performing, and above all those which taught me to love music, and how music can move you so deeply, regardless of its genre or style”.
The album also features duets with Tiziano Ferro, Juanes and Johnny Hallyday. It debuted at number one on the Italian Albums Chart and held the top spot for 8 non-consecutive weeks. It also became the best-selling album of 2006 in Italy, selling 500,000 copies in less than two months. On 8 November 2007, the album won Best Female Pop Vocal Album at the Latin Grammy Awards.[136] Laura dedicated the award to the memory of Italian tenor Luciano Pavarotti. Later on during the show she sang “Vivere (Dare to Live)” alongside Italian singer Andrea Bocelli.
In Summer 2006, Pausini played a Juntos en concierto tour with Marc Anthony and Marco Antonio Solís,[139] consisting of 20 concerts throughout the United States.
On 2 June 2007, Pausini was the first female artist to play at the San Siro Stadium in Milan, in front of a crowd of 70,000 spectators. On 30 November 2007, the concert was released on CD and DVD, under the title San Siro 2007.